Metabotropic Glutamate Receptors Inhibit Microglial Glutamate Release
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چکیده
منابع مشابه
Metabotropic glutamate receptors inhibit microglial glutamate release
Pro-inflammatory stimuli evoke an export of glutamate from microglia that is sufficient to contribute to excitotoxicity in neighbouring neurons. Since microglia also express various glutamate receptors themselves, we were interested in the potential feedback of glutamate on this system. Several agonists of mGluRs (metabotropic glutamate receptors) were applied to primary rat microglia, and the ...
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The effect of metabotropic glutamate receptor (mGluR) activation on vasopressin (VP) and oxytocin (OT) release was evaluated using explants of the hypothalamoneurohypophysial system. (+/-)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid (t-ACPD), an agonist at groups I and II mGluRs, increased VP and OT release in a concentration-dependent manner. A role for group I mGluRs in VP and OT release ...
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ژورنال
عنوان ژورنال: ASN Neuro
سال: 2012
ISSN: 1759-0914,1759-0914
DOI: 10.1042/an20120044